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Therapeutic vaccine candidates using viral vectors encoding LMP2 have productively induced virus-certain CD8⁺ T cell responses in early-phase medical trials. Moreover, adoptive T cell therapies like posoleucel also focus on LMP2 along with other latency proteins including EBNA1, reinforcing its importance as a conserved and immunodominant antigen.
Between these latency proteins, EBNA-3a plays a supportive but non-vital job in B mobile transformation: EBV mutants lacking EBNA-3a can nevertheless transform B cells, but with appreciably minimized efficiency.
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The most crucial danger here is damage to the devices required to preserve the gas during the reactor cool -- external electricity lines, unexpected emergency diesel turbines, tools to dissipate warmth with the reactor core, inside a war, fixing this devices or employing countermeasures might be not possible.
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"the gist with the prosecutor's argument"; "the guts and soul from the Republican Social gathering"; "the nub on the story"
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: a part faraway from the inside of the mass Particularly to learn the interior composition or simply a hidden ailment took a core